In order to advance to the Elite Eight, SU will have to pull off the biggest upset of the Sweet 16, against a team that beat them by 16 less than a month ago.
Duke is the only double digit favorite in the Sweet 16, nearly doubling the line of any other match-up. They Blue Devils won their first two games of the tournament by 22 and 25 points. Duke scored 176 points in those 2 games, while the Orange allowed just 161 points in 3 games to get to this point.
Kansas and Clemson get things started from Omaha just after 7 tonight, and then SU-Duke follows on CBS5 at approximately 9:30.